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Related Experiment Videos

Signet-ring chondrosarcoma: a new morphologic entity.

D J Demetrick1, P D Kneafsey, W S Hwang

  • 1Department of Pathology, University of Calgary Faculty of Medicine, Alberta, Canada.

Human Pathology
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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This case report describes the first instance of a "signet-ring" chondrosarcoma, a rare chest wall tumor. The diagnosis was confirmed through histology, immunostaining, and ultrastructural analysis, revealing aggressive features.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Pathology

Background:

  • Chondrosarcomas are malignant tumors arising from cartilage-forming cells.
  • Signet-ring morphology is typically associated with adenocarcinoma, not chondrosarcoma.
  • Anterior chest wall masses can present asymptomatically and be detected incidentally.

Observation:

  • A 65-year-old man presented with an asymptomatic anterior chest wall mass found on routine chest x-ray.
  • Initial fine needle aspirate suggested metastatic adenocarcinoma with signet-ring features.
  • Subsequent ultrastructural study and surgical resection confirmed a grade 2 chondrosarcoma.

Findings:

  • The chondrosarcoma exhibited prominent "signet-ring"-like cells containing lipid vacuoles.
  • Immunohistochemistry was positive for vimentin and S-100, supporting chondrosarcoma diagnosis.

Related Experiment Videos

  • Flow cytometry revealed a significant aneuploid cell population (50-60%), indicating aggressive potential.

    • Implications:

    • This case represents the first documented "signet-ring" chondrosarcoma.
    • The unusual morphology highlights the importance of comprehensive diagnostic evaluation, including ultrastructural studies.
    • Accurate diagnosis is crucial for appropriate treatment and management of aggressive chondrosarcomas.