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Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin
Kaori Sayanagi1, Fumi Gomi, Miki Sawa
1Department of Ophthalmology, Osaka University Medical School, Room E7, 2-2 Yamadaoka, 565-0871 Suita, Japan.
Purpose:
To report on the clinical features of three cases of polypoidal choroidal vasculopathy (PCV) during long-term follow-up after photodynamic therapy (PDT).
Design:
Interventional case reports.
Methods:
Among the participants in the Japanese Age-Related Macular Degeneration Trial (JAT) at our hospital, a PCV was seen in three eyes at baseline on retrospective analysis of indocyanine green angiography (ICGA) using fundus camera. We report the clinical features of these cases during more than 4 years follow-up.
Results:
The mean number of PDT treatments was 5.7. Improved visual acuity (VA) and cessation of fluorescein leakage was achieved within 18 months in all eyes; however, subretinal hemorrhage and subfoveal fluid recurred due to new or recurrent PCV. The final VA decreased markedly in two eyes.
Conclusions:
The eyes with PCV, which had been treated successfully with PDT, may have developed new or recurrent PCV during long-term follow-up. Periodical ICGA would be needed to detect abnormal choroidal vascular changes.