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Chorionic villus sampling significantly affects fetal cardiovascular function.

Nebojsa Radunovic1, Edward Kuczynski, Olivera Kontic

  • 1Institute of Obstetrics and Gynecology, University of Belgrade, Belgrade, Serbia.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|April 18, 2007
PubMed
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Chorionic villus sampling (CVS) can cause acute fetal hemodynamic changes, impacting fetal heart rate (FHR). These FHR alterations are influenced by gestational age and maternal age at the time of the procedure.

Area of Science:

  • Maternal-fetal medicine
  • Prenatal diagnostics

Background:

  • Chorionic villus sampling (CVS) is a common prenatal diagnostic procedure.
  • Understanding the immediate effects of CVS on fetal well-being is crucial.

Purpose of the Study:

  • To assess the impact of chorionic villus sampling (CVS) on fetal heart rate (FHR).

Main Methods:

  • A prospective longitudinal study involving 300 patients undergoing transabdominal CVS.
  • Fetal heart rate (FHR) and procedural details were recorded between 8 and 13 weeks of gestation.

Main Results:

  • Fetal heart rate (FHR) showed a significant inverse correlation with gestational age before CVS, which was lost post-procedure.
  • The change in FHR (delta FHR) increased with gestational and maternal age, and decreased with specimen weight.

Related Experiment Videos

  • Gestational age and maternal age were significant predictors of delta FHR, explaining over 22% of the variance.

    • Conclusions:

    • Chorionic villus sampling (CVS) is associated with acute fetal hemodynamic changes.
    • These fetal hemodynamic alterations are dependent on gestational age at the time of sampling.