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Updated: Jul 15, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation
Reo Tanoshima1, Hiroaki Goto, Masakatsu Yanagimachi
1Department of Pediatrics, Yokohama City University, Yokohama, Kanagawa, Japan.
Abstract:
A 13-month-old female underwent unrelated cord blood transplantation (CBT) for juvenile myelomonocytic leukemia (JMML). In spite of progression of the disease after a conditioning regimen with high-dose chemotherapy, a complete remission was induced in concordance with development of acute GVHD after reduction of the immunosupressant. She has been in complete remission for 1 year after transplantation. This case illustrates that CBT can provide a potent graft versus leukemia (GVL) effect against JMML.
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