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Updated: Jul 15, 2026
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[Complex analysis of prognostic factors in chronic lymphocytic leukemia]
Béla Kajtár1, Pál Jáksó, László Kereskai
1Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Patológiai Intézet, Pécs. bkajtar@pathology.pote.hu
Introduction:
Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival.
Aims:
The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.
Methods:
The mutation status of the IgH gene was evaluated in 160 cases.
Results:
In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.
Conclusions:
The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
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