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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Ocular circulation in diabetic patients with coronary artery disease

Sayuri Fujioka1, Kaoruko Karashima, Norikiyo Nishikawa

  • 1Department of Ophthalmology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamiti, Higashinari-ku, Osaka 537-8511, Japan. fujioka-sa@mc.pref.osaka.jp

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|April 18, 2007
PubMed

Insights

Diabetic patients with coronary artery disease (CAD) show reduced blood flow in the eyes, particularly during the diastolic phase. This ocular circulation change may be linked to decreased cardiac output in these patients.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Diabetology

Background:

  • Diabetic retinopathy is a common complication of diabetes mellitus.
  • Coronary artery disease (CAD) is prevalent in diabetic patients.
  • Ocular circulation changes may indicate systemic vascular dysfunction.

Purpose of the Study:

  • To assess ocular circulation using orbital color Doppler imaging in diabetic patients with and without coronary artery disease (CAD).
  • To correlate ocular hemodynamic changes with cardiac function in diabetic patients with CAD.

Main Methods:

  • Studied 30 diabetic patients with retinopathy (grades 20 or 35), divided into groups with and without CAD.
  • Performed ophthalmic examinations and orbital color Doppler imaging.
  • Included 15 healthy controls and echocardiography for the CAD group.

Main Results:

  • Diabetic patients with CAD exhibited significantly lower end-diastolic velocity in the central retinal artery.
  • Flattened diastolic blood flow waves were more common in orbital arteries of diabetic patients with CAD.
  • Echocardiography revealed reduced cardiac systolic and/or diastolic function in 67% of diabetic patients with CAD.

Conclusions:

  • Diabetic patients with CAD demonstrate decreased diastolic blood flow velocities in ocular vessels.
  • These findings suggest a potential link between impaired ocular circulation and reduced cardiac output in diabetic patients with CAD.
Abstract

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