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Published on: February 28, 2019
[Expression and significance of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp tissue]
Yuqin Deng1, Zezhang Tao, Jinhui Chen
1Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Objective:
To study the expression of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp and explore the different mechanism between polyposis and polyp.
Method:
Fifteen cases of nasal polyposis, thirteen cases of polyp and eight cases of normal middle turbinate were studied with immunohistochemical SP method to detect the expression of Eotaxin and Eotaxin-2.
Result:
There were significant differences between either two groups about the expression of Eotaxin-2 (P < 0.05). The expression of Eotaxin in nasal polyposis and polyp were dramatically higher than in controls (P < 0.05), the expression of Eotaxin between nasal polyposis and polyp was no remarkable difference (P > 0.05).
Conclusion:
Both of Eotaxin and Eotaxin-2 likely play key roles in the inflammatory reaction process of nasal polyposis and polyp. The different expression of Eotaxin-2 between nasal polyposis and polyp demonstrates it may be one of the main causes in the different mechanism of the two diseases.
