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Preparation of microcapsules with self-microemulsifying core by a vibrating nozzle method
Miha Homar1, Dasa Suligoj, Mirjana Gasperlin
1Lek Pharmaceuticals d.d., Research and development, Ljubljana, Slovenia.
Journal of Microencapsulation
|April 19, 2007
Summary
This study developed a novel method for creating solid dosage forms using self-microemulsifying systems (SMES) encapsulated in alginate microcapsules. This approach enhances drug delivery and offers a stable, reproducible manufacturing process for improved oral absorption.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Self-microemulsifying systems (SMES) improve drug dissolution and absorption but are challenging to formulate into solid dosage forms.
- Current SMES formulations are primarily liquid or soft gelatin capsules, limiting their application.
- Solid dosage forms offer advantages in handling, stability, and patient compliance.
Purpose of the Study:
- To explore the incorporation of self-microemulsifying systems (SMES) into microcapsules for solid dosage form development.
- To optimize the microencapsulation process for stable and reproducible production.
- To evaluate the encapsulation efficiency and drug loading of the developed microcapsules.
Main Methods:
- Utilized an Inotech IE-50 R encapsulator with a concentric nozzle for alginate microcapsule production.
- Optimized encapsulator parameters, shell-forming phase, and hardening solution to improve core phase retention.
- Characterized microcapsules for encapsulation efficiency and drug loading.
Main Results:
- Successfully produced alginate microcapsules containing a self-microemulsifying core.
- Achieved a mean encapsulation efficiency exceeding 87% with a drug loading of 0.07%.
- Demonstrated a stable and reproducible microencapsulation process.
Conclusions:
- Microencapsulation is a viable method for formulating self-microemulsifying systems into solid dosage forms.
- The developed process is stable and reproducible, paving the way for advanced drug delivery systems.
- This technology enhances the potential for improved oral drug absorption through solid dosage forms.
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