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Updated: Jul 15, 2026

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
Published on: January 22, 2019
Buckling of lipid tubules in shrinking liquid droplets
Yue Zhao1, Linan An, Jiyu Fang
1Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials, and Aerospace Engineering, University of Central Florida, Orlando, Florida 32816, USA.
Abstract:
Self-assembled hollow lipid tubules are interesting and potentially useful supramolecular structures. Here, we study the deformation of lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) trapped inside liquid droplets on glass substrates. The interface tension of the shrinking liquid droplets exerts a compression force on the ends of the trapped lipid tubules, and causes them to buckle. This provides a method to measure their mechanical properties. The Young's modulus of the DC8,9PC lipid tubules is estimated to approximately 1.07 GPa. As the strain energy of the buckled tubules builds up, they poke through the interface of shrinking liquid droplets and then adhere onto glass substrates to form looplike shapes.
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