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22q11.2 deletion syndrome: behaviour problems of infants and parental stress

W Briegel1, M Schneider, K O Schwab

  • 1Department of Child and Adolescent Psychiatry, Leopoldina Hospital, Gustav-Adolf-Strasse 4, 97422 Schweinfurt, Germany. wbriegel@leopoldina.de

Child: Care, Health and Development
|April 19, 2007
PubMed

Insights

Infants with 22q11.2 deletion syndrome (22q11.2 DS) may exhibit behavioral issues, but their caregivers experience lower parental stress than expected. Further research is needed on the long-term impact of 22q11.2 DS on behavior and stress.

Area of Science:

  • Pediatric Psychology
  • Developmental Pediatrics
  • Genetics

Background:

  • 22q11.2 deletion syndrome (22q11.2 DS) is linked to developmental delays and psychiatric disorders.
  • Limited data exists on early behavior problems and parental stress in 22q11.2 DS.
  • This study addresses the gap in understanding early behavior in 22q11.2 DS and its impact on caregivers.

Purpose of the Study:

  • To investigate behavior problems in infants with 22q11.2 DS.
  • To assess parental stress levels in primary caregivers of these infants.
  • To explore the relationship between child behavior and parental stress in 22q11.2 DS.

Main Methods:

  • Anonymous questionnaires were distributed to parents of infants with 22q11.2 DS.
  • The Child Behavior Checklist (CBCL) 1.5-5 was utilized to assess behavior.
  • Data from 22 families were analyzed, including child age, gender, and developmental status.

Main Results:

  • 17/21 children had motor delays, and 15/21 had language delays.
  • 5/21 children exhibited clinical behavior issues on the CBCL 1.5-5.
  • Caregiver stress was not elevated compared to the general population and was lower than parents of other handicapped children.
  • Child age correlated with anxiety, and girls showed more sleep problems than boys.
  • Parental stress correlated with externalizing and anxious/depressed behaviors.

Conclusions:

  • Infants with 22q11.2 DS can present with behavioral challenges.
  • Parental stress in this group is manageable and lower than in comparable populations.
  • Longitudinal studies are crucial to track the progression of behavior problems and parental stress over time.
Abstract

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