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[Inflammatory state in patients with atrial fibrillation before and after electrical cardioversion]

E Gómez Martínez1, S Borrás Pallé, F Valls Grima

  • 1Unidad Coronaria, Servicio de Medicina Intensiva, Hospital Universitario Dr. Peset, Valencia, España. gomez_eva@gva.es

Medicina Intensiva
|April 19, 2007
PubMed

Insights

Patients with atrial fibrillation show increased inflammation. While certain inflammatory markers were higher in those not successfully cardioverted, only high-sensitivity C-reactive protein (hs-CRP) showed a trend towards predicting recurrence.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Biomarker Discovery

Context:

  • Persistent atrial fibrillation is associated with an elevated inflammatory state.
  • Understanding inflammatory markers may predict cardioversion success and recurrence.
  • Assessing biomarkers like hs-CRP, IL-6, and TNF-alpha is crucial.

Purpose:

  • To evaluate the inflammatory status in patients with persistent atrial fibrillation.
  • To determine the predictive value of inflammatory markers for cardioversion success.
  • To assess the association of inflammation with atrial fibrillation recurrence at 30 days.

Summary:

  • A prospective study found elevated inflammatory markers (hs-CRP, IL-1β, IL-6, TNF-α) in atrial fibrillation patients compared to controls.
  • Tumor Necrosis Factor-alpha and Interleukin-6 were higher in non-cardiovertors, but only enlarged atria predicted cardioversion failure.
  • High-sensitivity C-reactive protein (hs-CRP) in the highest quartile trended towards predicting AF recurrence at 30 days.

Impact:

  • This research highlights the role of inflammation in atrial fibrillation pathophysiology.
  • Findings suggest potential utility for hs-CRP in risk-stratifying patients for AF recurrence.
  • Further investigation into inflammatory biomarkers could refine treatment strategies for atrial fibrillation.
Abstract

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