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Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis.

D Centonze1, F Petta, V Versace

  • 1Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy. centonze@uniroma2.it

Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 19, 2007
PubMed
Summary

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Repetitive transcranial magnetic stimulation (rTMS) over the motor cortex improved voiding symptoms in multiple sclerosis (MS) patients. This suggests enhancing corticospinal excitability may help manage MS-related bladder dysfunction.

Area of Science:

  • Neuroscience
  • Urology
  • Neurology

Background:

  • Multiple sclerosis (MS) frequently causes lower urinary tract symptoms (LUTS).
  • Bladder dysfunction in MS impacts quality of life.
  • Current treatments for MS-related LUTS have limitations.

Purpose of the Study:

  • To investigate the therapeutic potential of 5-Hz repetitive transcranial magnetic stimulation (rTMS) targeting the motor cortex.
  • To assess the effects of rTMS on voiding and filling lower urinary tract symptoms in MS patients.

Main Methods:

  • A cohort of multiple sclerosis patients with lower urinary tract symptoms underwent 5-Hz rTMS over the motor cortex.
  • Stimulation was administered for five consecutive days over a two-week period.
  • Micturition cycle phases (filling and voiding) were evaluated.

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Main Results:

  • Motor cortex rTMS significantly ameliorated the voiding phase of the micturition cycle.
  • Improvements suggest enhanced corticospinal tract excitability positively influences bladder function.
  • The treatment showed potential for improving detrusor contraction and/or urethral sphincter relaxation.

Conclusions:

  • Five days of 5-Hz rTMS over the motor cortex over two weeks is a promising non-invasive approach.
  • This intervention may help manage bladder voiding dysfunction in multiple sclerosis.
  • Enhancing corticospinal excitability offers a novel therapeutic avenue for MS-related bladder issues.