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Related Experiment Videos

Silsesquioxane nanocomposites as tissue implants.

Ruben Y Kannan1, Henryk J Salacinski, Jalal-Edin Ghanavi

  • 1London, United Kingdom; and Tehran, Iran From the Biomaterials and Tissue Engineering Center, Academic Division of Surgery and Interventional Sciences, University College London; Departments of Plastic and Reconstructive Surgery and Histopathology, Royal Free Hampstead NHS Trust; Nanomedicine Research Center, Shaheed Beheshti University of Medical Sciences; and Department of Materials Chemistry, Birkbeck College, University of London.

Plastic and Reconstructive Surgery
|April 19, 2007
PubMed
Summary
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A new polyhedral oligomeric silsesquioxane-poly(carbonate-urea)urethane (POSS-PCU) nanocomposite shows reduced inflammation and degradation compared to silicone implants. This novel biomaterial offers improved biocompatibility and stability for safer tissue implantation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Silicone implants are widely used for augmentation, but capsular contracture affects 15% of procedures.
  • Developing advanced biomaterials is crucial to mitigate implant-related complications.
  • A novel polyhedral oligomeric silsesquioxane-poly(carbonate-urea)urethane (POSS-PCU) nanocomposite has been engineered.

Purpose of the Study:

  • To evaluate the biocompatibility and stability of the POSS-PCU nanocomposite as a tissue implant.
  • To compare the performance of POSS-PCU against conventional silicone implants in a preclinical model.

Main Methods:

  • Implantation of POSS-PCU and siloxane (control) in sheep for 36 months.
  • Explantation and analysis of polymers and surrounding tissues.

Related Experiment Videos

  • Surface degradation assessment using spectroscopy; host interaction evaluation via histopathology and electron microscopy.

    • Main Results:

    • POSS-PCU exhibited minimal inflammation versus significant inflammation and degradation in siloxane controls.
    • POSS-PCU demonstrated increased fibrinogen adsorption and amphiphilicity, inhibiting inflammation.
    • No degradation was observed in the POSS-PCU nanocomposite, unlike the degrading siloxane control.

    Conclusions:

    • POSS-PCU nanocomposites offer superior interfacial biocompatibility and biological stability.
    • These enhanced properties make POSS-PCU a safer alternative to conventional silicone biomaterials for tissue implants.