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From dermal exposure to internal dose.

Johannes J M Van de Sandt¹, Mike Dellarco, Joop J Van Hemmen

¹TNO Quality of Life, Department of Food & Chemical Risk Analysis, Zeist, The Netherlands. han.vandesandt@tno.nl

Journal of Exposure Science & Environmental Epidemiology

|April 19, 2007

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Chemical risk assessments under REACH require dermal exposure and bioavailability data. Current methods are costly, but non-testing approaches like (Quantitative) Structure-Activity Relationships ((Q)SARs) can improve efficiency.

Area of Science:

Environmental Science
Toxicology
Regulatory Science

Background:

Chemical risk assessment under REACH (Registration, Evaluation, Authorisation and restriction of Chemicals) relies on exposure scenarios.
Dermal exposure and bioavailability are critical when the dermal route predominates.
Existing methods for dermal exposure assessment can be expensive and time-consuming.

Purpose of the Study:

To highlight the importance of dermal exposure and bioavailability data in chemical risk assessment.
To discuss the limitations of current methodologies.
To propose the expanded use of non-testing methods for dermal risk assessment under REACH.

Main Methods:

Review of existing methodologies for measuring dermal exposure (quantitative/semi-quantitative).

Related Experiment Videos

Discussion of data sources for dermal bioavailability (in vitro, animal experiments).

Exploration of non-testing methods, specifically (Quantitative) Structure-Activity Relationships ((Q)SARs).

Main Results:

Dermal exposure and bioavailability data are essential for accurate chemical risk assessment.
In-depth exposure assessments are often cost-prohibitive.
(Q)SARs for skin absorption are underutilized in regulatory contexts.

Conclusions:

Expanding the use of (Q)SARs can enhance the practicability of REACH.
Optimizing data generation for dermal risk assessment requires detailed exposure condition information.
Integrating non-testing methods can streamline regulatory processes for chemical safety.