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Painful ejaculation associated with antidepressants in four patients
D Aizenberg1, Z Zemishlany, H Hermesh
1Gehah Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.
The Journal of Clinical Psychiatry
|November 1, 1991
Summary
Tricyclic antidepressants like imipramine can cause painful ejaculation, a rare side effect. Reducing the dose or stopping the medication resolves this issue.
Area of Science:
- Pharmacology
- Psychiatry
- Urology
Background:
- Painful ejaculation is an uncommon adverse effect of tricyclic antidepressants (TCAs).
- Limited medical literature documents this specific side effect.
Purpose of the Study:
- To report and describe the occurrence of painful ejaculation in patients using TCAs.
- To raise awareness among clinicians about this underreported adverse event.
Main Methods:
- Case study of four patients experiencing painful ejaculation.
- Administration of imipramine and clomipramine as the causative agents.
Main Results:
- Painful ejaculation manifested within the first three weeks of TCA treatment.
- Symptoms resolved within days upon dose reduction or discontinuation of the medication.
Conclusions:
- Tricyclic antidepressant administration can evoke painful ejaculation.
- This adverse effect is underreported and clinicians should be vigilant.