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Updated: Jul 15, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Chemoselective C(sp3)-H bond activation for the preparation of condensed N-heterocycles
Hongjun Ren1, Zhuo Li, Paul Knochel
1Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Abstract:
Condensed N-heterocycles were prepared by using C-H activation reactions catalyzed by Pd(OAc)2 (5 mol %) and (p-tolyl)3P (10 mol %). The key step of these ring closures is chemoselective intramolecular C-H activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9H-pyrrolo[1,2-a]indoles and pyrrolo[1,2-f]phenanthridine derivatives were prepared in good yields. The preparation of some complex N-heterocycles by using successive reactions is also described.
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