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[Expression of AIB1 protein in gynecological tumors]
Xiao-Yan Han1, Xue-Mei Zhang, Yue Chen
1Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression of AIB1 (amplified in breast cancer 1) protein in gynecological cancers, and to analyze the role and clinical significance of AIB1 protein in carcinogenesis and development of gynecological cancers.
Methods:
By immunohistochemical method SP, we examined the AIB1 expression levels and relative clinico-pathological features in 10 normal cervical tissues and 18 cervical cancers; 18 normal endometrium tissues and 46 endometrium carcinoma; 19 normal ovarian tissues and 74 epithelial ovarian cancers.
Results:
The expression rate of AIB1 protein in cervical carcinoma wasn't higher than that in normal cervical tissues, but AIB1 expression was correlated with lymph node involvement. The positive expressions of AIB1 in carcinoma of endometrium and ovarian cancers were significantly higher than those in normal tissues. In carcinoma of endometrium, the rate of AIB1 expression in poorly-differentiated cancer was obviously higher than it in well-differentiated cancer. There was an inverse relationship between AIB1 expression levels and histological tumor grades (P = 0.02). It showed the tendency forward that the AIB1 expression increased with the progress of clinical stages (P = 0.006).
Conclusion:
The overexpression of AIB1 may play a role in the carcinogenesis and development of gynecological cancers, especially ovarian cancers.
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