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Detection of Protein Ubiquitination
Published on: August 19, 2009
UbiProt: a database of ubiquitylated proteins
Alexander L Chernorudskiy1, Alejandro Garcia, Eugene V Eremin
1Nizhny Novgorod State University, Nizhny Novgorod, Russia. chalbio@mail.ru <chalbio@mail.ru>
BMC Bioinformatics
|April 20, 2007
Summary
The UbiProt Database consolidates information on ubiquitylated proteins, addressing a critical need for systematized data in ubiquitylation research. This resource aids scientists studying protein ubiquitylation and its role in human diseases.
Area of Science:
- Molecular Biology
- Biochemistry
- Genomics
Background:
- Ubiquitylation, a key post-translational modification, significantly impacts cellular pathways and disease pathogenesis.
- While many eukaryotic proteins are ubiquitylated, data remains fragmented.
- Understanding ubiquitylation is crucial for advancing biological and medical research.
Purpose of the Study:
- To create a centralized, systematized knowledge base for ubiquitylated proteins.
- To address the need for organized experimental data on ubiquitylation.
- To provide a comprehensive resource for researchers in the ubiquitin field.
Main Methods:
- Development of the UbiProt Database, a novel resource for ubiquitylated proteins.
- Systematization of experimental data on protein ubiquitylation.
- Inclusion of protein characteristics, ubiquitylation sites, and related machinery.
Main Results:
- The UbiProt Database offers retrievable information on protein ubiquitylation.
- It includes details on ubiquitylation features, machinery, and supporting literature.
- The database is publicly accessible at http://ubiprot.org.ru.
Conclusions:
- UbiProt serves as a valuable public resource for comprehensive ubiquitylated protein information.
- It benefits researchers studying the ubiquitin system and specific ubiquitylated proteins.
- Ongoing development of UbiProt is anticipated to be of broad interest to the research community.
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