Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In hypertension, the kidney rules.

Steven D Crowley1, Thomas M Coffman

  • 1Nephrology, VA Medical Center, Durham, NC 27705, USA.

Current Hypertension Reports
|April 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure in Practice: A New Clinical Case Series in <i>Hypertension</i>.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Shedding light on the role of extracellular vesicles in renal fibrosis.

Fundamental research·2026
Same author

Urinary Branched-Chain Amino Acid Excretion and Chronic Kidney Disease Progression in Patients With Type 2 Diabetes.

Diabetes·2025
Same author

The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.

International journal of biological sciences·2025
Same author

Targeting PARylated RACK1/HIF-1<i>α</i> axis: A novel mechanism in acute kidney injury and therapeutic promise.

Acta pharmaceutica Sinica. B·2025
Same author

Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy.

Trends in pharmacological sciences·2025

The renin-angiotensin system (RAS) plays a key role in blood pressure regulation. New research highlights the kidney's critical function in hypertension by demonstrating that angiotensin II acting on renal AT1 receptors is essential for developing high blood pressure.

Area of Science:

  • Cardiovascular Physiology
  • Renal Pathophysiology
  • Endocrinology

Background:

  • The renin-angiotensin system (RAS) is a vital hormonal cascade regulating blood pressure and fluid balance.
  • Components of the RAS are found in various tissues, complicating the understanding of tissue-specific roles.
  • Previous studies suggested kidney sodium excretion is the primary RAS blood pressure regulatory mechanism.

Purpose of the Study:

  • To elucidate the specific role of the kidney within the RAS in the context of hypertension.
  • To differentiate the impact of RAS components in the kidney versus other tissues.
  • To confirm the necessity of renal angiotensin II type 1 (AT1) receptor activity in hypertension development.

Main Methods:

  • Utilized kidney cross-transplantation models.

Related Experiment Videos

  • Employed genetically engineered mouse models.
  • Investigated the effects of interrupting RAS components in specific tissue compartments.

    • Main Results:

    • Confirmed a significant role for angiotensin II acting via AT1 receptors within the kidney in promoting hypertension.
    • Demonstrated that these renal AT1 receptor actions are indispensable for angiotensin II-dependent hypertension.
    • Showed that renal AT1 receptor activity is required for cardiac hypertrophy associated with hypertension.

    Conclusions:

    • The kidney plays a critical, non-redundant role in the pathogenesis of hypertension.
    • Angiotensin II acting on renal AT1 receptors is a key driver of hypertension and its cardiovascular sequelae.
    • These findings underscore the importance of the kidney in RAS-mediated cardiovascular disease.