Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

System for study of diverse cellular composition in alveolar rhabdomyosarcoma.

Scientific reports·2026

Same author

Papillary Squamous Intraepithelial Lesion Outside the Uterine Cervix: Clinicopathological Characterization and Immunohistochemical Study.

The American journal of surgical pathology·2026

Same author

Dissecting the oncogenic function of YAP1 and WWTR1 fusion proteins in mammary epithelial cells.

Cancer letters·2026

Same author

Despite simplified diagnostic criteria, intraobserver and interobserver variability remain in the interpretation of colorectal serrated polyps.

Histopathology·2026

Same author

Prospective Identification of Dysplasia in Barrett's Esophagus With Combined Optical Coherence Tomography and Light Scattering Measurements.

Journal of biophotonics·2025

Same author

Durability of cryoballoon ablation for eradication of neoplastic Barrett's esophagus: a multicenter prospective cohort study (with video).

Gastrointestinal endoscopy·2025

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Pathology of soft tissue sarcoma.

Brian P Rubin¹, John R Goldblum

¹Department of Anatomic Pathology, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. rubinb2@ccf.org

Journal of the National Comprehensive Cancer Network : JNCCN

|April 20, 2007

Summary

Soft tissue sarcoma diagnosis and treatment require expert pathology. Pathologists are crucial for accurate diagnosis, classification, grading, and guiding treatment strategies for these complex tumors.

Area of Science:

Oncology
Pathology
Surgical Pathology

Background:

Soft tissue sarcomas present complex diagnostic and therapeutic challenges.
The pathologist is a key member of the multidisciplinary sarcoma treatment team.

Purpose of the Study:

To summarize the essential roles of the soft tissue pathologist in sarcoma management.
To outline current diagnostic and therapeutic evaluation methods for soft tissue sarcomas.

Main Methods:

Review of diagnostic methods including frozen section analysis.
Discussion of sarcoma classification, grading, and molecular pathology.
Emphasis on expert consultation and tumor banking.

Main Results:

Pathologists are integral to accurate soft tissue sarcoma diagnosis and classification.

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Related Experiment Videos

Last Updated: Jul 15, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Molecular pathology and grading are critical for treatment planning.

Effective tumor banking supports future research and patient care.

Conclusions:

The soft tissue pathologist's role is central to optimal sarcoma patient care.
Multidisciplinary collaboration and advanced diagnostic techniques improve outcomes.
Standardized approaches in pathology enhance the evaluation and treatment of soft tissue sarcomas.