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Published on: September 20, 2019
Continuous infusion of methylprednisolone via paediatric parenteral nutrition: a pharmacokinetic animal study
Christophe Gellis1, Valérie Sautou-Miranda, Nathalie Bleyzac
1Laboratoire de Pharmacie Clinique et Biotechnique, EA2416, Faculté de Médecine-Pharmacie, 28 Place Henri-Dunant, 63000, Clermont-Ferrand, France.
Background & Aims:
The aim of our study consisted to measure the pharmacokinetic parameters of methylprednisolone administered in a continuous infusion of a paediatric parenteral nutrition mixture for 24h in the rabbit.
Methods:
Fourteen rabbits were split into two groups and assigned a different administration vehicle (all-in-one or two-in-one nutrition mixture). We used USC PACK* pharmacokinetics software to compare the influence of the composition of the paediatric parenteral nutritional solutions on the values of the pharmacokinetic parameters of methylprednisolone.
Results:
Neither the steady-state plasma concentrations of methylprednisolone hemisuccinate nor the values of the pharmacokinetic parameters of methylprednisolone differed significantly when administered in two-in-one or all-in-one nutrition mixtures.
Conclusions:
The composition of the nutritional medium had no discernable effect on the bioavailability of methylprednisolone. Neither the speed at which the steady-state plasma concentration was reached, nor the values of the pharmacokinetic parameters of methylprednisolone were significantly modified.
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