Related Experiment Video
Updated: Jul 15, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs
Anders Vik1, Erik Hedner, Colin Charnock
1Department of Chemistry, University of Oslo, Blindern, N-0315 Oslo, Norway.
Abstract:
Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of microorganisms and cancer cells has been studied. Compounds with excellent activity against cancer cell lines (MIC ca. 1 microM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.
Related Concept Videos
Inhibitors of Bacterial Protein Synthesis
Antifungal Agents
Antimicrobial Effectiveness
Antiviral Nucleoside Inhibitors
Inhibitors of Gram-positive Cell Wall Synthesis
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...

