Reduced lactational performance following intravenous endotoxin administration to dairy cows

Nonpregnant lactating cows were given 100 micrograms of endotoxin via the jugular vein to determine effects of intravenous endotoxin administration on mammary inflammation and lactational performance. At the first milking (11 h) posttreatment, milk yield was reduced 33%. Milk fat percentage was elevated at this time, but lactose concentration was decreased. Milk yield and composition returned to pretreatment levels within 2 d. Clinical mastitis was not induced by endotoxin treatment, but milk SCC, NAGase, serum albumin, and lactoferrin were increased by 50%. This increase was small compared with increases during mastitis and may have resulted from lower milk volume. These results support the hypothesis that part of the reduced lactational performance during endotoxin mastitis is mediated by systemic pathophysiological responses and indicate that intravenous endotoxin administration may be a useful model to study adverse effects of infectious disease on lactational performance.