Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.

Developmental cell·2024
Same author

Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Cell reports·2024
Same author

Erratum.

The Journal of comparative neurology·2024
Same author

Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum.

The Journal of comparative neurology·2023
Same author

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.

Developmental biology·2023
Same author

Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis.

bioRxiv : the preprint server for biology·2023

Related Experiment Video

Updated: Jul 15, 2026

Placing Growth Factor-Coated Beads on Early Stage Chicken Embryos
09:25

Placing Growth Factor-Coated Beads on Early Stage Chicken Embryos

Published on: October 1, 2007

Patterning of frontal cortex subdivisions by Fgf17.

Jeremy A Cholfin1, John L R Rubenstein

  • 1Medical Scientist Training Program, University of California, San Francisco, CA 94143-2611, USA.

Proceedings of the National Academy of Sciences of the United States of America
|April 20, 2007
PubMed
Summary

Fibroblast growth factor 17 (Fgf17) is crucial for developing the frontal cortex (FC). Its absence shrinks the dorsal FC and shifts sensory areas, revealing its role in brain patterning.

More Related Videos

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation
07:03

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Published on: May 6, 2020

Related Experiment Videos

Last Updated: Jul 15, 2026

Placing Growth Factor-Coated Beads on Early Stage Chicken Embryos
09:25

Placing Growth Factor-Coated Beads on Early Stage Chicken Embryos

Published on: October 1, 2007

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation
07:03

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Published on: May 6, 2020

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The frontal cortex (FC) governs higher cognitive functions.
  • Genetic mechanisms underlying FC subdivision formation remain largely unknown.
  • Understanding these mechanisms is key to comprehending brain development and function.

Purpose of the Study:

  • To investigate the role of Fgf17 in the genetic control of frontal cortex subdivision.
  • To determine how Fgf17 influences the development and patterning of the FC.
  • To elucidate the specific contributions of Fgf17 to dorsal versus ventral FC formation.

Main Methods:

  • Utilized gene expression markers to distinguish newborn mouse FC subdivisions.
  • Analyzed the effects of Fgf17 loss on FC size and organization.
  • Examined the impact on sensory cortical area positioning.

Main Results:

  • Loss of Fgf17 selectively reduced the size of the dorsal FC.
  • Ventral/orbital FC regions appeared normal in Fgf17-deficient mice.
  • A rostral shift in sensory cortical areas was observed, indicating broader neocortical map alterations.

Conclusions:

  • Fgf17 plays a selective role in patterning the dorsal frontal cortex.
  • Fgf17 contributes to the establishment of functionally distinct FC subdivisions.
  • Fgf17's function in neocortical patterning is comparable to Fgf8 but with greater specificity for dorsal FC properties.