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Activity changes in monkey superior colliculus during saccade adaptation.

Norihito Takeichi1, Chris R S Kaneko, Albert F Fuchs

  • 1Department of Physiology and Biophysics and Regional Primate Research Center, University of Washington, Seattle, Washington 98195, USA.

Journal of Neurophysiology
|April 20, 2007
PubMed
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Saccade (eye movement) amplitude adaptation involves changes in superior colliculus (SC) neuron activity. Most tested SC neurons showed altered firing patterns during adaptation, suggesting the SC

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Motor Control

Background:

  • Saccades are rapid eye movements crucial for accurate target foveation.
  • Saccade amplitude requires continuous adjustment throughout life due to maturation, aging, and pathology.
  • The superior colliculus (SC) is a potential site for saccade adaptation, relaying cortical commands.

Purpose of the Study:

  • To investigate the role of the superior colliculus (SC) in saccade amplitude adaptation.
  • To resolve conflicting previous findings regarding the location of saccade adaptation mechanisms.
  • To examine SC burst neuron activity during optimized saccade adaptation conditions.

Main Methods:

  • Recorded activity of superior colliculus (SC) burst neurons during behavioral saccade adaptation.

Related Experiment Videos

  • Optimized experimental conditions to maximize neuronal activity changes during adaptation.
  • Analyzed changes in spike count, burst shape, and movement fields of SC neurons.

    • Main Results:

    • Behavioral saccade amplitude adaptation correlated with significant changes in spike count or movement fields in 35 of 43 SC neurons.
    • Changes in spike count occurred gradually, involving burst lead and duration, not peak rate.
    • A majority of SC neurons exhibited altered discharge patterns during saccade adaptation.

    Conclusions:

    • The superior colliculus (SC) plays a significant role in saccade amplitude adaptation.
    • SC neurons demonstrate adaptive changes in their firing patterns.
    • The SC may be the primary site of adaptation or the final common pathway for adaptive signals.