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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
Published on: December 24, 2015
Modulation of immune responses by mesenchymal stem cells
Willem E Fibbe1, Alma J Nauta, Helene Roelofs
1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, building 1, E3-Q, 2333 ZA Leiden, the Netherlands. W.E.Fibbe@LUMC.nl
Annals of the New York Academy of Sciences
|April 20, 2007
Summary
Mesenchymal stem cells (MSCs) are not inherently immune privileged. Allogeneic MSCs can trigger immune responses and potential graft rejection, even after nonmyeloablative conditioning, impacting MSC therapy efficacy.
Area of Science:
- Immunology
- Stem Cell Biology
- Transplantation Medicine
Background:
- Mesenchymal stem cells (MSCs) are investigated for their immunomodulatory properties.
- Their potential in cell-based therapies relies on their ability to manage immune responses.
Purpose of the Study:
- To investigate the immunogenicity of allogeneic mesenchymal stem cells (MSCs) in immunocompetent hosts.
- To determine if MSCs are intrinsically immune privileged and their behavior post-transplantation.
Main Methods:
- In vivo studies involving cotransplantation of allogeneic MSCs in immunocompetent hosts.
- Assessment of immune responses and graft status following sublethal irradiation and MSC administration.
Main Results:
- Mesenchymal stem cells (MSCs) are not intrinsically immune privileged.
- Allogeneic MSCs can induce memory T cell responses and alloresponses in vivo.
- Graft rejection can occur even after nonmyeloablative conditioning, indicating preserved MSC immunogenicity.
Conclusions:
- The immunogenicity of allogeneic MSCs is not fully abrogated by nonmyeloablative conditioning.
- Further research is needed to understand MSC immunogenicity following myeloablative conditioning regimens.
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