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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
The complex link between oxidised low-density lipoprotein and unstable angina
Giampaolo Niccoli1, Rocco Mongiardo, Gaetano A Lanza
1Institute of Cardiology, Catholic University, Rome, Italy. gniccoli73@hotmail.it
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|April 20, 2007
Summary
Oxidised low-density lipoprotein (ox-LDL) in plaques did not differ between stable and unstable angina. However, higher circulating ox-LDL levels in unstable angina correlate with complex lesions, suggesting a role in coronary artery disease activity.
Area of Science:
- Cardiovascular Research
- Atherosclerosis
- Lipid Metabolism
Background:
- Oxidised low-density lipoprotein (ox-LDL) is implicated in atherosclerosis.
- The specific role of ox-LDL in plaque destabilisation remains debated.
- Comparing ox-LDL in stable versus unstable ischaemic syndromes is crucial for understanding disease progression.
Purpose of the Study:
- To compare plaque and plasma ox-LDL levels in patients with stable angina (SA) and unstable angina (UA).
- To investigate the correlation between ox-LDL (plaque and plasma) and angiographic indicators of complex stenosis morphology.
Main Methods:
- Study included 10 SA and 10 UA patients undergoing directional coronary atherectomy.
- Plaque sections were immunostained for ox-LDL using specific monoclonal antibodies (mAb-4E6 and mAb-1H11).
- Plasma ox-LDL quantified by ELISA; C-reactive protein measured; angiographic analysis performed.
Main Results:
- Plaque ox-LDL content (mAb-4E6 or mAb-1H11) was similar in SA and UA groups.
- Plasma ox-LDL levels were significantly higher in UA patients compared to SA patients (P=0.03).
- Plasma ox-LDL correlated significantly with the number of complex lesions (P=0.03) and C-reactive protein levels (P=0.04).
Conclusions:
- Plaque ox-LDL does not appear to be a primary driver of coronary plaque instability.
- Circulating ox-LDL may play a role in plaque vulnerability and overall coronary artery disease activity.
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