Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear transport: target for therapy.

R S Faustino1, T J Nelson, A Terzic

  • 1Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minnesota, USA.

Clinical Pharmacology and Therapeutics
|April 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral Health, Inflammation, and Cardiometabolic Factors in the VA Million Veteran Program.

JDR clinical and translational research·2024
Same author

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics.

Clinical pharmacology and therapeutics·2017
Same author

Affairs of the Heart: Innovation in Cardiovascular Research and Development.

Clinical pharmacology and therapeutics·2017
Same author

Clinical Pharmacology & Therapeutics: Past, Present, and Future.

Clinical pharmacology and therapeutics·2017
Same author

Managing Innovation to Maximize Value Along the Discovery-Translation-Application Continuum.

Clinical pharmacology and therapeutics·2016
Same author

Differential antioxidant properties of red wine in water soluble and lipid soluble peroxyl radical generating systems.

Molecular and cellular biochemistry·2016
Same journal

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.

Clinical pharmacology and therapeutics·2026
Same journal

Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

Clinical pharmacology and therapeutics·2026
Same journal

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

Clinical pharmacology and therapeutics·2026
Same journal

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

Clinical pharmacology and therapeutics·2026
Same journal

Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

Clinical pharmacology and therapeutics·2026
Same journal

Composite Endpoints in Contemporary Cardiovascular Trials: Trends in Phase 3 Trials and Key Issues in Regulatory Review.

Clinical pharmacology and therapeutics·2026
See all related articles

New therapeutic strategies are emerging by targeting intracellular signaling pathways and nuclear transport. Understanding nucleocytoplasmic exchange offers promising anticancer, antiviral, and anti-inflammatory treatments.

Area of Science:

  • Cellular Biology
  • Pharmacology
  • Molecular Medicine

Background:

  • Plasma membrane receptor drugs are standard in clinical pharmacology.
  • Intracellular signaling mechanisms offer new therapeutic targets.
  • The nuclear envelope and transport machinery are key in cellular regulation.

Purpose of the Study:

  • To explore novel therapeutic avenues by targeting intracellular signaling and nucleocytoplasmic exchange.
  • To highlight the potential of nuclear transport modulation for disease intervention.

Main Methods:

  • Analysis of intracellular signaling pathways.
  • Investigation of nuclear transport mechanisms.
  • Exploration of nucleocytoplasmic exchange dynamics.

Related Experiment Videos

Main Results:

  • Interventions at cytosol-organellar interfaces show therapeutic promise.
  • The nuclear envelope and transport machinery are central to developing new therapeutics.
  • Nucleocytoplasmic exchange insights reveal potential anticancer, antiviral, and anti-inflammatory strategies.

Conclusions:

  • Targeting intracellular and nuclear transport mechanisms represents a significant frontier in drug discovery.
  • Modulating nucleocytoplasmic exchange offers a versatile approach for treating various diseases.