Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis A. Perspectives and recent advances.

J E Maynard

    The American Journal of Pathology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified the hepatitis A virus using immune electron microscopy. This 27 nm virus is distinct from hepatitis B and can cause disease in primates.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    At-birth immunisation against hepatitis B using a novel pre-filled immunisation device stored outside the cold chain.

    Vaccine·1999
    Same author

    The introduction of new vaccines into developing countries.

    Vaccine·1999
    Same author

    Lombok Hepatitis B Model Immunization Project: toward universal infant hepatitis B immunization in Indonesia.

    The Journal of infectious diseases·1995
    Same author

    Surveillance of hepatitis delta virus infection in Colombia, South America.

    Progress in clinical and biological research·1991
    Same author

    Recovery of hepatitis A virus from a water supply responsible for a common source outbreak of hepatitis A.

    American journal of public health·1990
    Same author

    Hepatitis B: global importance and need for control.

    Vaccine·1990
    Same journal

    Lxrα Deficiency Primes Retinal Degeneration, but Aging Drives Disease Severity.

    The American journal of pathology·2026
    Same journal

    MYC is functionally required in both normal and neoplastic Meibomian glands.

    The American journal of pathology·2026
    Same journal

    Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis.

    The American journal of pathology·2026
    Same journal

    Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

    The American journal of pathology·2026
    Same journal

    APOE4 as a Modifier of Chemotherapy Response.

    The American journal of pathology·2026
    Same journal

    Spatial Pathobiology in the Omics Era: Transforming Modern Pathology.

    The American journal of pathology·2026
    See all related articles

    Area of Science:

    • Virology
    • Hepatology
    • Infectious Diseases

    Background:

    • Viral hepatitis, specifically hepatitis A and B, has been studied for decades.
    • Differentiation between hepatitis A and B was primarily based on epidemiological and etiological factors.
    • Direct visualization and isolation of the hepatitis A virus remained elusive until recent advancements.

    Purpose of the Study:

    • To isolate and visualize the etiologic agent of hepatitis A.
    • To confirm the viral nature of hepatitis A through serological and experimental methods.
    • To aid in the definitive differentiation between hepatitis A and hepatitis B.

    Main Methods:

    • Application of immune electron microscopy to clinical specimens.
    • Collection of stool samples from patients in the early acute stages of hepatitis A.

    Related Experiment Videos

  • Morphological characterization of isolated virus-like particles.
  • Serological testing for antibody development.
  • Inoculation of nonhuman primates with purified viral fractions.

    • Main Results:

    • Successful recovery and visualization of 27 nm virus-like particles from hepatitis A patient stools.
    • Demonstration of specific antibody development against these particles during hepatitis A infection, absent in hepatitis B.
    • Induction of disease in nonhuman primates following inoculation with purified particle fractions.
    • Morphological homogeneity of the recovered particles.

    Conclusions:

    • The identified 27 nm particles are the etiologic agent of hepatitis A.
    • Hepatitis A virus is antigenically distinct from hepatitis B virus.
    • The virus can experimentally induce disease in susceptible animal models.
    • Hepatitis A virus classification is pending, with potential links to parvoviruses or enteroviruses.