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Related Experiment Video

Updated: Jul 15, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Selective estrogen receptor modulators (SERMs) for uterine leiomyomas.

X Lingxia¹, W Taixiang, C Xiaoyan

¹West China Hospital, Sichuan University, Clinical Medicine, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041. kitty_xlx@yahoo.com.cn

The Cochrane Database of Systematic Reviews

|April 20, 2007

Summary

Selective estrogen receptor modulators (SERMs) show a tendency for uterine fibroid reduction, but evidence for effectiveness and safety is limited. More research is needed to confirm benefits for women with uterine fibroids.

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Last Updated: Jul 15, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Area of Science:

Gynecology
Pharmacology
Oncology

Background:

Uterine fibroids are common benign uterine smooth muscle tumors.
Selective estrogen receptor modulators (SERMs) have variable estrogenic and anti-estrogenic effects.
Previous studies on SERMs for uterine fibroids yielded controversial results.

Purpose of the Study:

To evaluate the effectiveness and safety of SERMs for treating uterine fibroids.
To synthesize evidence from randomized controlled trials on SERM efficacy.

Main Methods:

Comprehensive literature search across multiple databases including Cochrane Library, MEDLINE, and Chinese databases.
Inclusion of randomized controlled studies comparing SERMs with placebo or other medical therapies.
Narrative data synthesis due to heterogeneity and quality limitations of included studies.

Main Results:

Three studies with 215 participants were included.
A trend towards fibroid size reduction with SERMs was observed, but not statistically significant in all cases.
Adverse reactions were reported but lacked detailed data.

Conclusions:

Limited evidence suggests SERMs do not significantly reduce uterine fibroid size or improve clinical outcomes.
Further high-quality research is necessary to establish the therapeutic benefits of SERMs for uterine fibroids.