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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Selective estrogen receptor modulators (SERMs) for uterine leiomyomas.
X Lingxia1, W Taixiang, C Xiaoyan
1West China Hospital, Sichuan University, Clinical Medicine, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041. kitty_xlx@yahoo.com.cn
The Cochrane Database of Systematic Reviews
|April 20, 2007
Summary
Selective estrogen receptor modulators (SERMs) show a tendency for uterine fibroid reduction, but evidence for effectiveness and safety is limited. More research is needed to confirm benefits for women with uterine fibroids.
Area of Science:
- Gynecology
- Pharmacology
- Oncology
Background:
- Uterine fibroids are common benign uterine smooth muscle tumors.
- Selective estrogen receptor modulators (SERMs) have variable estrogenic and anti-estrogenic effects.
- Previous studies on SERMs for uterine fibroids yielded controversial results.
Purpose of the Study:
- To evaluate the effectiveness and safety of SERMs for treating uterine fibroids.
- To synthesize evidence from randomized controlled trials on SERM efficacy.
Main Methods:
- Comprehensive literature search across multiple databases including Cochrane Library, MEDLINE, and Chinese databases.
- Inclusion of randomized controlled studies comparing SERMs with placebo or other medical therapies.
- Narrative data synthesis due to heterogeneity and quality limitations of included studies.
Main Results:
- Three studies with 215 participants were included.
- A trend towards fibroid size reduction with SERMs was observed, but not statistically significant in all cases.
- Adverse reactions were reported but lacked detailed data.
Conclusions:
- Limited evidence suggests SERMs do not significantly reduce uterine fibroid size or improve clinical outcomes.
- Further high-quality research is necessary to establish the therapeutic benefits of SERMs for uterine fibroids.
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