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Acid and gastric ulcer pain
Journal of Clinical Gastroenterology
|October 1, 1991
Summary
Gastric ulcer pain is significantly linked to acid exposure. Infusing hydrochloric acid (HCl) into gastric ulcers caused typical pain in most patients, unlike saline.
Area of Science:
- Gastroenterology
- Pathophysiology
- Clinical Medicine
Background:
- Acid is a known factor in duodenal ulcer pain pathogenesis.
- The role of acid in gastric ulcer pain requires further elucidation.
Purpose of the Study:
- To investigate the direct role of acid in causing pain in patients with gastric ulcers.
Main Methods:
- Gastric ulcer patients underwent endoscopy without sedation.
- Ulcer craters were infused sequentially with 0.1 N hydrochloric acid (HCl) and normal saline in a randomized, double-blind manner.
Main Results:
- Seven out of 19 patients reported typical ulcer pain during acid infusion, compared to one patient with saline (p = 0.023).
- Recurrence of typical pain was observed in two patients upon re-infusion of acid after pain subsided.
Conclusions:
- Hydrochloric acid plays a definitive role in the pathogenesis of gastric ulcer pain.
- Direct acid instillation can provoke pain in individuals with gastric ulcers.