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Updated: Jul 15, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
[Comparative analysis of modern combined methods in diagnosis of renal cell carcinoma]
Abstract:
To ascertain the role of multispiral computed tomography (MSCT) in diagnosis of renal cell carcinoma (RCC) and to propose optimal diagnostic policy in RCC patients, we examined 63 patients with suspected renal tumor: 37 (59%) males and 26 (41%) females, age 47-77 ages, mean age 54.2+/-1.5 years, duration of the disease from 1 month to 7 years. The following diagnostic methods were imployed: ultrasonography of the kidneys, plain and excretory urography, spiral computed tomography, angiography, MSCT, MRT, thin-needle aspiration biopsy. By the results of a combined examination and operation on the kidney lesion, the diagnosis of RCC was made in 45 (80.3%) patients including stage I in 21 (46.7%), stage II in 9 (20%), stage III in 13 (28.9%), stage IV in 2 (4.5%) patients. Benign renal tumors were detected in 8 (14.2%) patients, giant cysts of the kidneys--in 5 cases, benign renal tumors--in 3 cases, adenoma--in 2 cases, angiomyolipoma--in 1 case. Detected were also renal malformations in 3 cases, a distant retroperitoneal metastasis of RCC in 1 case, adrenal tumors in 6 (9.5%) cases. We suppose that MSCT enables multiplanar and 3-dimentional reconstruction of the images, staging of RCC, planning of surgical treatment. MSCT should be conducted after standard ultrasound examination.

