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Updated: Jul 15, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
Published on: November 21, 2025
[Effects of alpha-tocopherol on partial functions of the ischemic kidney]
Abstract:
The experiments on 45 rats and 20 rabbits were made to investigate antiischemic efficacy of alpha-tocopherol in respect of various partial functions of the kidneys compared to its antioxidant activity. It is demonstrated that administration of alpha-tocopherol prior to 30-min heat ischemia arrests activation of membrane lipid peroxidation (LPO) in the tissue of ischemic kidney both in rabbits and rats. Rabbit filtration renal function 1 hour after circulation recovery improved insignificantly, 24 hours after the recovery no difference with the control was registered, while secretory and reabsorption functions of the renal tubules under conditions of pretreatment with alpha-tocopherol significantly improved both in rabbits and rats both 1 hour and 24 hours after ischemia. Estimation of Ca-ATP activity of a microsomal fraction of the cortical substance of the ischemic kidneys has detected alpha-tocopherol induced suppression of LPO in sub-cellular membrane and high activity of this enzyme. Mechanisms of different protective action of alpha-tocopherol on renal glomeruli and tubules are discussed.
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Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

