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Generation of live-cell microarrays by means of DNA-Directed immobilization of specific cell-surface ligands

Hendrik Schroeder1, Bernhard Ellinger, Christian F W Becker

  • 1Biologisch-Chemische Mikrostrukturtechnik, Fachbereich Chemie, Universität Dortmund, Dortmund, Germany.

Angewandte Chemie (International Ed. in English)
|April 21, 2007
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...