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Updated: Jul 15, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Bruising: when it is spontaneous and not idiopathic thrombocytopenia purpura
Amanda L Davey1, Sarah-Jane Foxton, Pronab Bala
1Department of Paediatrics, Airedale General Hospital, Steeton, West Yorkshire, UK. amanda.davey@anhst.nhs.uk
Insights
Transient acquired inhibitors of coagulation can cause spontaneous bruising in children. This rare condition should be considered when common causes of bruising are excluded.
Area of Science:
- Pediatrics
- Hematology
Background:
- Bruising in children frequently raises concerns for non-accidental injury.
- A thorough differential diagnosis is crucial for evaluating pediatric bruising.
Observation:
- A 22-month-old boy presented with concerning bruising.
- Extensive investigations excluded common causes of bruising, including trauma and bleeding disorders.
Findings:
- The patient was diagnosed with transient acquired inhibitors of coagulation.
- This rare condition led to spontaneous bleeding episodes.
Implications:
- Highlights the importance of considering rare hematological conditions in pediatric bruising.
- Emphasizes the need for awareness of acquired coagulation inhibitors among clinicians.
- Underscores the diagnostic challenge when common causes are ruled out.
Abstract:
Bruising is a presentation that often causes concern. There are many causes of bruising in children, including non-accidental injury, which must be excluded. We report a case of a 22-month-old boy where all the common diagnoses were excluded. We highlight the need to be aware of transient acquired inhibitors of coagulation that can cause spontaneous bleeding.
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