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Clinical importance of HLA-DPB1 in haematopoietic cell transplantation

B E Shaw1, T Gooley, J A Madrigal

  • 1Department of Haematology, Nottingham City Hospital, Nottingham, UK. bshaw@doctors.org.uk

Tissue Antigens
|April 21, 2007
PubMed

There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

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