Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A multi-centre real-world evaluation of AI-assisted organ at risk contouring on radiotherapy treatment planning workflows.

The British journal of radiology·2026

Same author

Epidemiology and clinical management of 1072 dogs with diabetes mellitus in a UK diabetes register.

Companion animal health and genetics·2026

Same author

Rapid review: Three ways local government could improve inequality, public health and wellbeing outcomes in supported housing in England.

Public health in practice (Oxford, England)·2026

Same author

Creating a healthier economy: A rapid evidence review of inequalities in flexible working arrangements in the UK.

Public health in practice (Oxford, England)·2025

Same author

Opioid analgesics: Managing the predictable.

Clinical medicine (London, England)·2025

Same author

Rapid review: Ten ways to improve support for minoritised informal adult carers at local government policy level to redress inequality.

Public health in practice (Oxford, England)·2024

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Canine DLA diversity: 3. Disease studies.

L J Kennedy¹, A Barnes, A Short

¹Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. Lorna.Kennedy@manchester.ac.uk

Tissue Antigens

|April 21, 2007

Summary

This study explored canine leukocyte antigen (DLA) associations with canine diabetes and hypothyroidism. Findings reveal significant DLA links to both autoimmune diseases in dogs, offering insights into disease genetics.

More Related Videos

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Published on: May 24, 2016

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

Published on: January 31, 2022

Related Experiment Videos

Last Updated: Jul 15, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Published on: May 24, 2016

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

Published on: January 31, 2022

Area of Science:

Veterinary Medicine
Immunogenetics
Canine Health

Background:

Millions of dogs worldwide serve various roles, from companionship to specialized work.
Canine health and welfare are significant concerns for owners, breeders, and users of working dogs.
Dogs develop diseases mirroring human conditions, making them valuable animal models for genetic research.

Purpose of the Study:

To investigate the association between the canine leukocyte antigen (DLA) complex and specific autoimmune diseases in dogs.
To identify potential genetic markers in dogs that could inform human disease research.

Main Methods:

The study focused on identifying associations between DLA and two common canine autoimmune diseases.
Specific genetic markers within the DLA region were analyzed in relation to disease status.

Main Results:

Significant associations were discovered between DLA and canine diabetes.
A notable link was also found between DLA and canine hypothyroidism.
These findings suggest a genetic predisposition influenced by the DLA region for these conditions.

Conclusions:

The canine leukocyte antigen (DLA) complex plays a role in the development of autoimmune diseases like diabetes and hypothyroidism in dogs.
Identifying these genetic associations in dogs can provide valuable insights for understanding and potentially treating similar conditions in humans.