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Updated: Jul 15, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Acquired stenosis of normally connected pulmonary veins
Shanta Chakrabarti1, Ralph Mittal, James P Gnanapragasam
1Bristol Congenital Heart Centre, Bristol Royal Hospital for Children, Bristol United Kingdom.
Insights
Pediatric pulmonary venous stenosis, often acquired in infancy, presents a grave challenge with poor outcomes. Early recognition and intervention are critical for improving survival in affected infants.
Area of Science:
- Cardiology
- Pediatric Surgery
Background:
- Pulmonary venous stenosis (PVS) poses a significant challenge in pediatric cardiology.
- While acquired PVS in adults often has a favorable prognosis, its pediatric counterpart is poorly recognized and associated with dismal outcomes.
Observation:
- This study focuses on 7 infants who initially had normal pulmonary veins.
- These infants subsequently developed acquired pulmonary venous stenosis.
Findings:
- Acquired PVS in infants leads to significant morbidity and mortality.
- The condition in childhood is not well-recognized and presents with non-specific symptoms.
Implications:
- Highlights the critical need for increased awareness and research into pediatric acquired PVS.
- Emphasizes the importance of early diagnosis and management strategies to improve outcomes for affected infants.
Abstract:
Pulmonary venous stenosis has been a challenge to paediatric cardiologists and surgeons. In spite of significant improvements in the management and outcome of various congenital cardiac problems, the prognosis of this condition continues to be dismal. Acquired stenosis of the pulmonary veins has been described in the adult population, especially after radiofrequency ablation for atrial arrhythmias. The outcome of this condition has generally been described to be favourable in the long term. Acquisition of pulmonary venous stenosis in childhood has a very different outcome, and is not a very well recognised entity, with symptoms and signs which are non-specific. We present 7 infants who, when first assessed, had normal pulmonary veins, but who subsequently acquired stenoses of the veins, with very significant resultant morbidity and mortality.
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