Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caffeine challenge test in panic disorder and depression with panic attacks.

Antonio E Nardi1, Fabiana L Lopes, Alexandre M Valença

  • 1Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro RJ-22410-003, Brazil. antonionardi@terra.com.br

Comprehensive Psychiatry
|April 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Current pharmacological challenges of Treatment-Resistant Depression.

Pharmacological research·2026
Same author

From the Scientific Underground to the Height of Recognition: The 40th Anniversary of Rita Levi-Montalcini's Nobel Prize and the Promising Horizon in Psychiatry.

Neurochemical research·2026
Same author

Kenneth Bancroft Clark and the moral arc of psychological science: Reflections 20 years after his passing.

Journal of the history of the neurosciences·2026
Same author

Bridging Local Realities and Global Science: Psychiatric Education at 35 Years of Brazil's Sistema Único de Saúde.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2026
Same author

Nathan S. Kline: From the first treatments of psychosis and depression, a 70-year legacy of a pioneer of psychopharmacology.

Journal of psychopharmacology (Oxford, England)·2026
Same author

The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults.

Frontiers in psychiatry·2026

Patients with panic disorder (PD) and major depression with panic attacks (MDP) show increased sensitivity to caffeine. This caffeine challenge test reveals a hyperreactivity in individuals experiencing panic attacks, differentiating them from those with major depression without panic attacks and healthy volunteers.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Panic disorder (PD) and major depression with panic attacks (MDP) are distinct conditions.
  • Understanding the physiological response to stimuli like caffeine can elucidate underlying mechanisms.
  • Previous research suggests a link between caffeine consumption and anxiety symptoms.

Purpose of the Study:

  • To investigate if patients with PD and MDP exhibit similar responses to a caffeine challenge test.
  • To compare the panic attack induction rates between PD, MDP, major depression without panic attacks (MD), and healthy controls.
  • To assess the association between panic attacks and caffeine-induced hyperreactivity.

Main Methods:

  • A randomized, double-blind, placebo-controlled study.

Related Experiment Videos

  • Participants included patients with PD (n=29), MDP (n=27), MD (n=25), and healthy volunteers (n=28).
  • A 480 mg oral caffeine challenge was administered on two separate occasions, with anxiety scales measured before and after.

    • Main Results:

    • A significantly higher proportion of patients with PD (58.6%) and MDP (44.4%) experienced panic attacks after caffeine compared to MD patients (12.0%) and controls (7.1%).
    • Patients with PD and MDP demonstrated greater sensitivity to caffeine's panic-inducing effects.
    • No panic attacks were induced by the placebo. Patients with MD showed a lower heart rate response.

    Conclusions:

    • Panic attacks, whether in PD or MDP, are associated with hyperreactivity to oral caffeine challenge.
    • Caffeine challenge can serve as a useful tool to differentiate individuals prone to panic attacks.
    • These findings highlight a shared physiological vulnerability in panic-related disorders.