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Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis

Futoshi Anan1, Tsuyoshi Shimomura, Masaharu Imagawa

  • 1Department of Cardiology, Oita Red Cross Hospital, Oita, Japan. anan-f@med.oita-u.ac.jp

Metabolism: Clinical and Experimental
|April 21, 2007
PubMed

Insights

Hepatocyte growth factor (HGF) may predict silent cerebral infarctions (SCIs) in hemodialysis patients. Higher HGF levels were linked to increased SCI risk, suggesting HGF as a novel predictor for cerebrovascular events in chronic kidney disease.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiovascular Research

Background:

  • Silent cerebral infarctions (SCIs) are linked to high mortality in hemodialysis (HD) patients.
  • Hepatocyte growth factor (HGF) levels rise with renal dysfunction and may predict cerebrovascular events.

Purpose of the Study:

  • To investigate if HGF is a predictor of SCIs in patients undergoing hemodialysis.
  • To identify risk factors associated with SCIs in this patient population.

Main Methods:

  • 50 hemodialysis patients were divided into groups with and without SCIs based on MRI.
  • 24-hour ambulatory blood pressure monitoring was performed.
  • Plasma HGF levels, lipid profiles, and demographic data were analyzed.

Main Results:

  • The SCI group had higher HGF levels (P < .005) and lower HDL cholesterol.
  • Smokers and higher nocturnal systolic blood pressure and heart rate were more prevalent in the SCI group.
  • HGF was identified as a significant risk factor for SCI (OR, 1.89; P < .005).

Conclusions:

  • HGF is a potential novel predictor of SCIs in patients with chronic renal failure on hemodialysis.
  • Elevated HGF levels may indicate an increased risk for cerebrovascular events in this cohort.

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