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Updated: Jul 15, 2026

Bilayer Microfluidic Device for Combinatorial Plug Production
Published on: December 1, 2023
Multiphase flow in microfluidic systems --control and applications of droplets and interfaces
Lingling Shui1, Jan C T Eijkel, Albert van den Berg
1BIOS/Lab-on-a-Chip Group, MESA+ Research Institute, University of Twente, P.O. Box 217, 7500AE Enschede, The Netherlands. L.shui@ewi.utwente.nl
Abstract:
Micro- and nanotechnology can provide us with many tools for the production, study and detection of colloidal and interfacial systems. In multiphase flow in micro- and nanochannels several immiscible fluids will be separated from each other by flexible fluidic interfaces. The multiphase coexistence and the small-volume confinement provide many attractive characteristics. Multiphase flow in microfluidic systems shows a complicated behavior but has many practical uses compared to a single-phase flow. In this paper, we discuss the methods of controlling multiphase flow to generate either micro- or nano-droplets (or bubbles) or stable stratified interfaces between fluidic phases. Furthermore, applications of the droplets and interfaces in microchannels are summarized.
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