Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Noncovalent interactions with DNA: an overview.

Lucjan Strekowski1, Beth Wilson

  • 1Department of Chemistry, Georgia State University, Atlanta, GA 30302-4098, United States. lucjan@gsu.edu

Mutation Research
|April 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging Large Language Models to Generate Multiple-Choice Questions for Ophthalmology Education.

JAMA ophthalmology·2025
Same author

Ophthalmic Knowledge Assessment Program Scores and Written Qualifying Examination Performance.

JAMA ophthalmology·2025
Same author

A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the <i>Drosophila</i> Ventral Nerve Cord.

bioRxiv : the preprint server for biology·2024
Same author

Re-imagining transdisciplinary education work through liminality: creative third space in liminal times.

Australian educational researcher·2022
Same author

Coping experiences of young adults diagnosed with a chronic illness: a qualitative systematic review protocol.

JBI evidence synthesis·2021
Same author

Assistive technologies that support social interaction in long-term care homes: a scoping review.

JBI evidence synthesis·2021
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

Small organic compounds that bind to DNA can disrupt cellular processes, offering potential anti-cancer and anti-viral applications. Understanding DNA binding modes, like groove binding and intercalation, is key to developing effective therapeutic agents.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Medicinal Chemistry

Background:

  • Small organic compounds noncovalently binding to nucleic acids have been extensively studied for four decades.
  • These interactions can disrupt DNA replication and transcription, leading to cell death.
  • This mechanism underlies the potential of DNA-binding compounds as anti-cancer and anti-viral agents.

Purpose of the Study:

  • To provide an overview of various DNA-binding modes.
  • To emphasize DNA groove specificity for groove-binding and intercalation.
  • To discuss factors influencing the binding mode and complex formation.

Main Methods:

  • Literature review of DNA-interacting agents.
  • Analysis of DNA-binding modes, focusing on groove binding and intercalation.

Related Experiment Videos

  • Discussion of ligand structural features and DNA sequence effects.

    • Main Results:

    • Most DNA-interacting agents exhibit selective binding via either groove binding or intercalation.
    • Some compounds demonstrate the ability to engage in both binding modes.
    • The preferred binding mode is determined by the DNA sequence and ligand structure.

    Conclusions:

    • DNA-binding compounds represent a promising class of therapeutic agents.
    • Specificity in DNA binding (groove vs. intercalation) is crucial for drug design.
    • The interplay between ligand structure and DNA sequence dictates binding affinity and mode.