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On imparting radiopacity to a poly(urethane urea).

Nirmala R James1, A Jayakrishnan

  • 1Polymer Chemistry Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum 695 012, Kerala, India.

Biomaterials
|April 21, 2007
PubMed
Summary

Researchers developed a radiopaque polyurethane urea (PUU) by incorporating 3,4,5-triiodobenzoic acid (TIB) into the polymer backbone. This modification enhanced radiopacity without significantly compromising the original polymer properties.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Poly(urethane urea) (PUU) is a versatile polymer with applications in various fields.
  • Radiopaque materials are essential for medical imaging and diagnostics.
  • Developing radiopaque polymers without compromising mechanical properties is a significant challenge.

Purpose of the Study:

  • To synthesize a radiopaque poly(urethane urea) (PUU) by incorporating 3,4,5-triiodobenzoic acid (TIB).
  • To characterize the radiopaque PUU and evaluate the impact of TIB modification on its properties.
  • To optimize reaction conditions for successful radiopaque modification.

Main Methods:

  • Synthesis of PUU from 2,4-toluene diisocyanate (TDI), polyethylene glycol (PEG), and ethylenediamine (ED).

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  • Radiopaque modification by attaching TIB onto the PUU backbone.
  • Characterization using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and X-radiography.

    • Main Results:

    • Successful synthesis of radiopaque PUU with TIB incorporation.
    • FTIR analysis confirmed the preservation of the hydrogen-bonded structure of PUU.
    • TGA showed unchanged degradation characteristics, while DSC indicated a shift in one glass transition to a lower temperature.
    • X-radiography confirmed the radiopaque nature of the modified polymer.

    Conclusions:

    • The attachment of TIB onto the PUU backbone successfully rendered the polymer radiopaque.
    • The modification minimally affected the hydrogen-bonded structure and degradation profile of PUU.
    • Altered thermal characteristics, including a shifted glass transition, are attributed to inter-phase mixing and altered chain packing due to bulky iodine atoms.
    • This radiopaque PUU shows potential for applications requiring X-ray visibility without significant property degradation.