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Updated: Jul 15, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents
Sabrina B Ferreira1, Marilia S Costa, Núbia Boechat
1Universidade Federal do Rio de Janeiro Departamento de Química Orgânica, Instituto de Química, Cidade Universitária, 21949-900 Rio de Janeiro, RJ, Brazil.
Abstract:
Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.
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