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Updated: Jul 15, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
ISG20, an actor of the innate immune response
Genevieve Degols1, Patrick Eldin, Nadir Mechti
1UMR5160 CNRS, EFS, 240 Avenue Emile Jeanbrau, 34094 Montpellier Cedex 5, France.
Abstract:
The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Recent studies that highlight the implication of the 3'-5' exonuclease ISG20 (IFN Stimulated Gene product of 20 kDa) in the host's defenses against pathogens are summarised in this review.
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