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Related Experiment Video

Updated: Jul 15, 2026

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

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Published on: July 29, 2017

Versican expression in human cervical cancer.

J Kodama¹, Hasengaowa, T Kusumoto

¹Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. kodama@cc.okayama-u.ac.jp

European Journal of Cancer (Oxford, England : 1990)

|April 21, 2007

Summary

High versican expression in cervical cancer correlates with increased tumor invasion and metastasis. This finding suggests versican may serve as a key biomarker for predicting poor prognosis in patients with cervical cancer.

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Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Versican is implicated in tumor invasion and metastasis.
Limited characterization of versican expression in cervical cancer exists.

Purpose of the Study:

To investigate versican protein expression in human cervical cancers.
To analyze the correlation between versican expression and clinicopathological features and patient outcomes.

Main Methods:

Immunohistochemical analysis of versican protein expression.
Study included 174 cases of human cervical cancer.
Correlation analysis with clinicopathological features and patient survival.

Main Results:

Stromal versican expression was significantly higher in patients with lymph node metastasis (p<0.0001).
Epithelial versican expression was elevated in non-squamous cell carcinoma, lymph-vascular space invasion, lymph node metastasis, and ovarian metastasis.
High epithelial versican expression independently predicted poor disease-free survival.

Conclusions:

Versican enrichment in tumor tissue is associated with cervical cancer progression.
Versican expression serves as a potential indicator of poor prognosis in cervical cancer patients.