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Updated: Jul 15, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Structures of new cytotoxic antibiotics, piericidins C7 and C8
Yoichi Hayakawa1, Shingo Shirasaki, Takashi Kawasaki
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. hykw@rs.noda.tus.ac.jp
Abstract:
Two new cytotoxic antibiotics, piericidins C7 (1) and C8 (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11,12-epoxide and 12-butenyl groups.
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