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Rationale, design, methods and baseline characteristics of the Asklepios Study
Ernst-R Rietzschel1, Marc L De Buyzere, Sofie Bekaert
1Department of Cardiovascular Diseases, Ghent University Hospital, Ghent, Belgium. errietzschel@yahoo.com
Summary
The Asklepios Study investigates ageing, cardiovascular haemodynamics, and inflammation in preclinical cardiovascular disease. It aims to predict disease risk using novel integrated haemodynamic phenotypes and telomere length.
Area of Science:
- Cardiovascular Medicine
- Gerontology
- Biomedical Engineering
Background:
- Cardiovascular disease (CVD) risk factors and preclinical changes are crucial for early detection.
- Ageing significantly impacts cardiovascular health, influencing haemodynamics and inflammation.
- Longitudinal studies are essential for understanding disease progression and identifying novel risk factors.
Purpose of the Study:
- To explore the interplay between ageing, cardiovascular haemodynamics, and inflammation in preclinical CVD.
- To develop and validate 'integrated' haemodynamic phenotypes for improved CVD risk prediction.
- To assess leukocyte telomere length as a marker of biological ageing in relation to CVD.
Main Methods:
- Longitudinal population study of 2524 participants (35-55 years old) free from overt CVD.
- Comprehensive baseline assessments including questionnaires, risk factors, biochemistry, vascular/cardiac structure and function (e.g., intima-media thickness, arterial distension).
- Novel integrated non-invasive biomechanical assessment combining modeling, hydraulic measurements, and system identification; peripheral blood leukocyte telomere length measurement.
Main Results:
- Sex-specific baseline risk factor and biochemical data are provided.
- The study established a cohort with detailed baseline cardiovascular and ageing parameters.
- Methodology for integrated haemodynamic phenotyping and telomere length assessment was implemented.
Conclusions:
- The Asklepios Study provides a robust dataset for investigating ageing, haemodynamics, and CVD emergence.
- Integrated haemodynamic phenotypes and telomere length hold promise for enhanced CVD risk stratification.
- The study aims to uncover novel risk factors and mechanistic insights into cardiovascular disease processes.
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