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Plasma soluble CD30 level correlates negatively with age in children

Jung Yu Chen1, Lin Shien Fu, Jao Jia Chu

  • 1Division of Immunology, Rheumatology and Allergy, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|April 21, 2007
PubMed

Insights

CD30 is not a reliable marker for atopic diseases in children, as its levels do not differ between atopic and non-atopic groups. Soluble CD30 (sCD30) levels inversely correlate with age in both groups.

Area of Science:

  • Immunology
  • Pediatric Allergy

Background:

  • Atopic diseases are linked to immune dysregulation, specifically T helper cell type 1/2 (Th1/Th2) imbalances.
  • CD30 is hypothesized as a marker for Th2-mediated immunity.

Purpose of the Study:

  • To evaluate CD30 as a marker for atopy and Th2 immune predominance in children.
  • To investigate the relationship between CD30 expression and atopic status in a pediatric cohort.

Main Methods:

  • Assessed surface CD30 expression on T and B lymphocytes in 61 children with atopy and 27 controls.
  • Measured plasma soluble CD30 (sCD30) levels in the same participants.

Main Results:

  • No significant differences were observed in surface CD30 expression on lymphocytes between atopic and control children.
  • Plasma sCD30 levels did not differ between the atopic and control groups.
  • A strong negative correlation between sCD30 levels and age was found in both control (r = -0.72) and atopic (r = -0.45) children.

Conclusions:

  • CD30 is not a suitable surrogate marker for atopic disease or Th2 immune responses in children.
  • Age is a significant factor influencing sCD30 levels and must be considered in future research.
Abstract

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